![]() The origin and clonal relationship of these isotype variants have been unclear. ![]() One unusual feature of hairy cells (HCs) is the frequent expression of multiple immunoglobulin heavy chain isotypes, with dominance of immunoglobulin (Ig)–G3, but only a single light chain type. Analysis of immunoglobulin variable region genes has revealed somatic mutation in most cases, consistent with an origin from a cell that has encountered the germinal center. Hairy cell leukemia (HCL) derives from a mature B cell and expresses markers associated with activation.
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